Host-schistosome interactions mediated by cross-species microRNA

Author: ZHANG Jing⁃yu ; QIN Ming ; FANG Jing-jing ; LI Jia-yi ; ZHANG Xin-xin ; ZHOU Fang-bin ; HE Xing
Publication Type:Review
Keywords: miRNA; schistosome; host; cross-species regulation
From: China Tropical Medicine 2022;22(12):1201-
CountryChina
Language:Chinese
Abstract: Abstract: Schistosomiasis is a serious major parasitic disease that threatens human life and health. A better understanding of the mechanism of host-schistosome interactions is the key to designing new prevention and control strategies. MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules, which lead to the degradation of the target messenger RNA (mRNA) or inhibition of its translation in a sequence-specific manner. Both schistosome and its host produce miRNAs, which can be secreted by extracellular vesicles (EVs). There is accumulating evidence that miRNAs from schistosome can be taken up by host cells, and finely manipulate the phenotype of host cells for their survival or pathogenesis in a cross-species manner, even inhibiting the growth and metastases of hepatoma cells. It is still unknown whether host free miRNAs can be taken up by schistosome, but this phenomenon is highly probable. miRNA-mediated cross-species regulation has emerged as a novel mechanism for host-schistosome interactions, and this review summarizes the advances in this regard.
Full text:18.Host-schistosome interactions mediated by cross-species.pdf