Research advances in the function of ferroptosis in ocular disease
10.3980/j.issn.1672-5123.2023.6.13
- VernacularTitle:铁死亡在常见眼科疾病中的研究进展
- Author:
Zi-Xuan YANG
1
;
Wei HAN
1
Author Information
1. Eye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine;Zhejiang University Eye Hospital, Hangzhou 310009, Zhejiang Province, China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
iron metabolism;
corneal disease;
age-related macular degeneration;
diabetic retinopathy
- From:
International Eye Science
2023;23(6):947-952
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of cell death that has been discovered in recent years and differs markedly from previously known cell death. The mechanism of ferroptosis is the inactivation of glutathione peroxidase(GPX)and the accumulation of lethal intracellular lipid peroxides that occur on the basis of cellular iron overload. Changes such as cell membrane rupture, mitochondrial crest reduction, and outer mitochondrial membrane shrinkage rupture can be observed under electron microscopy. Current studies have found that many diseases in ophthalmology involve ferroptosis-related processes such as iron overload, the imbalance of redox homeostasis, the inactivation of GPX, and accumulation of lethal levels of lipid hydroperoxides, which identified the important role of ferroptosis in ocular disease. This review focuses on the mechanism of ferroptosis and its role in corneal injury, cataract, glaucoma, age-related macular degeneration and diabetic retinopathy, which helps to sort out the pathological mechanisms of common ocular diseases and provide new ideas for the prevention and treatment of ocular diseases.
