Progress of mass spectrometry-based proteomics technology andits application of radiation
10.13491/j.issn.1004-714X.2021.01.024
- VernacularTitle:基于质谱的蛋白质组学技术的发展及其在辐射领域的应用
- Author:
Jiaqi XIANG
1
;
Qingjie LIU
1
;
Chengfang WANG
1
;
Mei TIAN
1
Author Information
1. Key laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088 China.
- Publication Type:ReviewArticles
- Keywords:
Proteomics;
Mass spectrometry;
Ionizing radiation;
Biomarkers;
DNA Damage
- From:
Chinese Journal of Radiological Health
2021;30(1):110-116
- CountryChina
- Language:Chinese
-
Abstract:
Proteomics was first proposed by Marc Wikins, et al in 1995. It refers to the investigation of all the proteins expressed in a set of genomes. With the development of mass spectrometry technology, it more and more extensively apply to the field of radiation. In particular, due to the widespread application of nuclear and radiation technologies has greatly increased, the probability of nuclear and radiation accidents, and the exposure of large-scale populations are increased. Therefore, simple, rapid, and high-throughput measurement of acute radiation exposure is necessary. The application of proteomics technology to study the molecular biological effects of radiation and the discovery of radiation biomarkers provide the possibility for rapid high-through put dose assessment. We reviewed the recent development of proteomics and its application in the field of radiation.
