A research review of mechanism and genetic susceptibility of lens opacity induced by low-dose ionizing radiation
10.13491/j.issn.1004-714X.2022.01.022
- VernacularTitle:低剂量电离辐射致眼晶状体混浊机制及遗传易感性研究现状
- Author:
Yu GAO
1
;
Yinping SU
1
;
Quanfu SUN
1
Author Information
1. Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088 China.
- Publication Type:ReviewArticles
- Keywords:
Low-dose ionizing radiation;
Cataract;
Ocular lens opacity;
Mechanism;
Genetic susceptibility
- From:
Chinese Journal of Radiological Health
2022;31(1):124-128
- CountryChina
- Language:Chinese
-
Abstract:
The lens of the eye has been recognized as one of the most radiosensitive tissues. It has been known that a radiation dose of 0.5 Gy or higher can induce radiation cataract. Studies have also demonstrated that long-term exposure to low-dose radiation can increase the risk of lens opacity. However, the specific biologic mechanism of lens opacity induced by low-dose ionizing radiation is still unclear. Many mechanism chains may induce opacity independently or jointly, such as genomic damage in lens epithelial cells, oxidative stress, defects in intercellular communication, and inflammatory reaction, and genetic and epigenetic factors may also play a role. This paper briefly reviews the mechanisms of low-dose ionizing radiation inducing lens opacity as well as the role of genetic susceptibility in its development and progression, in order to provide a scientific reference for the prevention and control of this disease.
