Establishment and application of normal human brain 18F-FDG PET database with NeuroQ software
10.13491/j.issn.1004-714X.2022.02.018
- VernacularTitle:基于NeuroQ的正常人脑18F-FDG PET数据库建立与应用
- Author:
Hongbo FENG
1
;
Jinghui XIE
1
;
Ya GAO
1
;
Lei LI
1
;
Yanjun ZHANG
1
Author Information
1. Nuclear Medical Department, the First Affiliated Hospital to Dalian Medical University, Dalian 116011 China.
- Publication Type:OriginalArticles
- Keywords:
Positron emission tomography;
Normal database;
Brain;
Quantitative analysis
- From:
Chinese Journal of Radiological Health
2022;31(2):229-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a local human brain 18F-fluorodeoxyglucose positron emission tomography (PET) database with NeuroQ software, and to test its practical value. Methods With NeuroQ software, the PET images of 93 selected subjects were analyzed, and the results were used to create a local normal human database. The metabolism characteristics of the local population were obtained by comparing the original data of the local database with those of the built-in software database, and the difference in case analysis was compared between the two databases. Results Compared with the built-in database, the local database showed the region with high metabolic rate concentrated in the frontal lobe (right superior frontal gyrus: 4.61%, right middle frontal gyrus: 4.49%, left superior frontal gyrus: 3.77%, and left middle frontal gyrus: 3.11%), right posterior cingulate gyrus (6.28%), right inferior parietal lobule (2.46%), left inferior parietal lobule (2.66%), the region with reduced metabolism mainly in the right cerebellum (−3.57%), left cerebellum (−5.27%), and pons (−3.59%). For case analysis, the local database generated results were better consistent with the clinical assessment results of cases. Conclusion Establishment of a local database would eliminate the differences in regions and acquisition conditions, which is of great value to improve the accuracy of diagnosis.
