Association between neonatal birth weight and maternal type 2 diabetes mellitus: a bidirectional Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2023.05.004
- Author:
SHEN Fangru
;
YANG Ke
;
LIU Houpu
;
ZHU Jiahao
;
LI Yingjun
- Publication Type:Journal Article
- Keywords:
birth weight;
type 2 diabetes mellitus;
Mendelian randomization
- From:
Journal of Preventive Medicine
2023;35(5):384-387,409
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association between neonatal birth weight and maternal type 2 diabetes (T2DM), so as to provide insights into the formulation of the early T2DM prevention and improvements of maternal and children health.
Methods:Single-nucleotide polymorphisms (SNPs) were collected from two genome-wide association studies (GWAS) that examined the association between neonatal birth weight and maternal T2DM. Inverse variance weighted method was employed for forward Mendelian randomization with 26 birth weight-associated SNPs as instrumental variables and maternal T2DM as the study outcome and for reverse Mendelian randomization with 18 maternal T2DM-associated SNPs as instrumental variables and maternal effects of neonatal birth weight as the study outcome. The heterogeneity was examined using Cochran's Q test, and the pleiotropy was evaluated using MR-Egger regression, while the robustness of the results was evaluated using leave-one-out test.
Results:Cochran's Q test detected heterogeneity across two studies (P=0.019, 0.038), and random effect models were employed. Mendelian randomization showed that an increase in neonatal birth weight by per standard error (approximately 488 g) resulted a 29.9% reduction in the risk of maternal T2DM (OR=0.701, 95%CI: 0.547-0.899), and maternal T2DM increased the neonatal birth weight by 0.074 standard errors (OR=1.074, 95%CI: 1.043-1.106). No horizontal pleiotropy was seen for instrumental variables (P=0.241, 0.188). With each SNP excluded in turn, the results of Mendelian randomization study were robust.
Conclusion :There are bidirectional associations between neonatal birth weight and risk of maternal T2DM.
- Full text:新生儿出生体重与母亲2型糖尿病关联的双向孟德尔随机化研究.pdf
