Research progress of cell death in radiation protection and radiosensitization
10.13491/j.issn.1004-714X.2023.02.024
- VernacularTitle:细胞死亡在辐射防护与放疗增敏中的研究进展
- Author:
Maoye TIAN
1
;
Hongmei NIE
1
;
Ya LIU
1
;
Wei LIU
1
;
Wei LONG
1
Author Information
1. Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192 China.
- Publication Type:Journal Article
- Keywords:
Ionizing radiation;
Cell death;
Radiation protection;
Radiosensitization
- From:
Chinese Journal of Radiological Health
2023;32(2):216-222
- CountryChina
- Language:Chinese
-
Abstract:
The rapid advances in technology and medicine have greatly facilitated the application of ionizing radiation. Clinically, radiotherapy is one of the major treatments for malignant tumors. However, besides killing tumor cells, ionizing radiation inevitably leads to radiation damage and even death of normal cells. How ionizing radiation causes cell death and the forms of cell death have always been important research topics in this field. Recently, several forms of cell death induced by irradiation have been discovered. Apart from apoptosis, pyroptosis, necroptosis, ferroptosis, autophagic cell death, and methuosis have gradually become research hotspots, and provide new targets for the development of radioprotective drugs and radiosensitizers. In this review, we summarize various forms of ionizing radiation-induced cell death and related molecular mechanisms. We also introduce the latest progress in radiation protection and radiosensitization based on these cell death mechanisms. This review will provide a reference for the research and development of radioprotective drugs and radiosensitizers in the future.
