Research progress on the role of macrophages in post-transplantation chronic rejection
10.3969/j.issn.1674-7445.2023.03.006
- VernacularTitle:巨噬细胞在移植后慢性排斥反应中的作用研究进展
- Author:
Difei REN
1
;
Tao LIAO
;
Yun MIAO
Author Information
1. Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Chronic rejection;
Macrophage;
Fibrosis;
Inflammation;
Graft vascular disease;
Repair;
Actin
- From:
Organ Transplantation
2023;14(3):358-
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is the optimal treatment for end-stage organ failure. Nevertheless, rejection remains an important factor affecting the allograft survival. At present, acute rejection may be effectively treated, whereas no effective interventions are available for post-transplantation chronic rejection. Long-term chronic rejection may lead to graft failure and severely affect long-term survival rate of allografts. In recent years, the role of macrophages in post-transplantation chronic rejection has gradually captivated increasing attention. In this article, main pathological changes of chronic rejection, the diversity and functional differences of macrophages involved in chronic rejection, and the role and mechanism of macrophages in chronic rejection were reviewed, and research progresses on macrophage-related treatment for chronic rejection were summarized, aiming to provide reference for the study of macrophages in post-transplantation chronic rejection.
