Triamcinolone Acetonide combined with Aflibercept in the treatment of wet age-related macular degeneration with poor response to Ranibizumab
10.3980/j.issn.1672-5123.2023.5.26
- VernacularTitle:曲安奈德联合阿柏西普治疗雷珠单抗应答不良的湿性年龄相关性黄斑变性
- Author:
Qian-Qian YANG
1
;
De-Cheng LIU
1
;
Wei GUAN
1
;
Yi LIU
1
Author Information
1. Department of Ophthalmology, the 7th People's Hospital of Zhengzhou, Zhengzhou 450016, Henan Province, China
- Publication Type:Journal Article
- Keywords:
wet age-related macular degeneration;
Triamcinolone Acetonide;
Aflibercept;
best corrected visual acuity;
central retinal thickness
- From:
International Eye Science
2023;23(5):852-855
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the efficacy and safety of intravitreal injection of aflibercept combined with posterior sub-fascial injection of triamcinolone acetonide in the treatment of wet age-related macular degeneration(ARMD)with poor response to anti-vascular endothelial growth factor drugs.METHODS: Retrospective cohort study. From June 2018 to May 2020, a total of 60 patients(60 eyes)with refractory ARMD who had poor response to the treatment of anti VEGF drug ranibizumab were randomly divided into the control group of aflibercept and the observation group of triamcinolone acetonide combined with aflibercept, with 30 patients(30 eyes)in each group. Once a month, the patients in the two groups received intravitreal injection of aflibercept alone or intravitreal injection of aflibercept combined with posterior sub-fascial injection of triamcinolone acetonide for three consecutive times. The changes of best corrected visual acuity(BCVA), central macular thickness(CMT)and intraocular pressure were reviewed before injection and 1, 3 and 6mo after the third injection.RESULTS: The BCVA and CMT of the two groups were significantly improved 1, 3 and 6mo after the injection of the drug(P<0.05). The mean intraocular pressure in the combined group was higher at 1mo after treatment than before, but it still within the normal range. There was a significant difference in intraocular pressure between the two groups(17.50±4.60 vs. 18.30±3.73mmHg, P<0.05).CONCLUSION: Triamcinolone acetonide injection under the posterior fascia of the eyeball combined with intravitreal injection of aflibercept in the treatment of wet ARMD can effectively reduce macular edema and improve vision, which is more safe and reliable.
