Progress on the antitumor activity of cryptotanshinone and its derivatives
10.12206/j.issn.2097-2024.202208090
- VernacularTitle:隐丹参酮及其衍生物抗肿瘤活性研究进展
- Author:
Ping WEN
1
;
Junping ZHANG
1
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.
- Keywords:
cryptotanshinone;
derivatives;
anti-tumor;
mechanism
- From:
Journal of Pharmaceutical Practice
2023;41(4):207-211
- CountryChina
- Language:Chinese
-
Abstract:
Cryptotanshinone is one of the effective components of traditional Chinese medicine salvia miltiorrhiza which shows good activities against a variety of tumors. Its anti-tumor effects include inhibition of tumor cell proliferation, induction of cell apoptosis, inhibition of cell migration and invasion, regulation of immune function and reversal of drug resistance. The direct anti-tumor targets include signal transducer and activator of transcription 3 (STAT3), tyrosine protein phosphatase SHP2, DNA topoisomerase 2, and other mechanisms of action include the induction of reactive oxygen species (ROS) production, regulation of estrogen and androgen receptor signaling, and inhibition of PI3K/AKT signaling pathway. In addition, many cryptotanshinone derivatives have been designed and synthesized to study the antitumor effects. The research progress of the antitumor activity of cryptotanshinone and its derivatives were reviewed in this paper to give references to the anti-tumor drug development of cryptotanshinone and its derivatives.
