Mechanism of Ferroptosis in Chinese Medicine Treatment of Heart Failure： A Review
10.13422/j.cnki.syfjx.202202029
- VernacularTitle:铁死亡在中医药治疗心力衰竭中的机制研究进展
- Author:
Haoran ZHOU
1
;
Jie YANG
2
;
Xin ZHUANG
2
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250000， China
2. Affiliated Hospital of Shandong University of TCM， Jinan 250011， China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
Chinese medicine;
heart failure;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(11):240-246
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is the final stage of heart disease caused by a variety of etiologies and has a high morbidity， mortality， and disability rate， making it a major challenge in the field of medicine. Cardiomyocytes， the most basic unit of the heart， are irreversible in nature and can be damaged or necrotic in various ways in the presence of heart failure. Myocardial cell injury is also an important cause of cardiac dysfunction and affects the prognosis and quality of life of patients. Therefore， reducing the level of myocardial cell damage and delaying the process of cell death can help patients with heart failure lessen the extent of cardiac damage and improve their prognosis， thereby lowering the incidence of death and disability and times of hospitalization. Ferroptosis is a new form of cell death that has been widely concerned in recent years， with studies confirming its occurrence in cardiac myocytes. As a modifiable form of cell death， interfering with ferroptosis can modulate the extent of injury and death in cardiac myocytes. Studies have shown that the inhibition of iron death has a protective effect on cardiomyocytes， thereby alleviating heart failure. Chinese medicine has been widely used in the clinical treatment of heart failure， and has the advantages of multiple approaches and entry points， with significant therapeutic effects， low side effects， and low medical costs. It also reduces the clinical side effects of western medicine， with good clinical results. The use of Chinese medicine to modulate ferroptosis may be a new direction for the future treatment of heart failure. This paper briefly elaborated on the mechanism of ferroptosis， investigated the role of ferroptosis in heart failure， and discussed the current status of research on ferroptosis in Chinese medicine interventions in heart failure， to provide references for further improving the efficacy of Chinese medicine in the treatment of heart failure.
