Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing.
10.3760/cma.j.cn501225-20220816-00348
- VernacularTitle:Wnt/
β连环蛋白信号通路在体表创面愈合中的作用机制研究进展
- Author:
Qian WU
1
;
Xiao Yu TAN
1
;
Yi Jia WANG
1
;
Shao Wen CHENG
2
;
Hong Wang CUI
2
;
Jiang Ling YAO
2
Author Information
1. Hainan Medical University, Haikou 570105, China.
2. Department of Emergency and Trauma Surgery, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Wnt Signaling Pathway;
Cell Differentiation;
Cell Movement;
Cell Proliferation;
Inflammation;
Wound Healing
- From:
Chinese Journal of Burns
2023;39(2):190-195
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing is a slow and complex biological process, including inflammatory reaction, cell proliferation, cell differentiation, cell migration, angiogenesis, extracellular matrix deposition, tissue remodeling, and so on. Wnt signaling pathway can be divided into classical pathway and non-classical pathway. Wnt classical pathway, also known as Wnt/β-catenin signaling pathway, plays an important role in cell differentiation, cell migration, and maintenance of tissue homeostasis. Many inflammatory factors and growth factors are involved in the upstream regulation of this pathway. The activation of Wnt/β-catenin signaling pathway plays an important role in the occurrence, development, regeneration, repair and related treatment of skin wounds. This article review the relationship between Wnt/β-catenin signaling pathway and wound healing, meanwhile summarizes its effects on important processes of wound healing, such as inflammation, cell proliferation, angiogenesis, hair follicle regeneration, and skin fibrosis, as well as the role of inhibitors of Wnt signaling pathway in wound healing.
