The regulatory role and related mechanisms of macrophages in wound healing.
10.3760/cma.j.cn501225-20230110-00010
- VernacularTitle:巨噬细胞在创面愈合中的调节作用及其相关机制
- Author:
Wei Feng HE
1
;
Ling Feng YAN
1
Author Information
1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Inflammation;
Macrophages;
Wound Healing
- From:
Chinese Journal of Burns
2023;39(2):106-113
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing is a complex process under precise regulation, including multiple stages such as inflammation, anti-inflammatory, and regeneration. Macrophages play an important regulatory role in the differentiated process of wound healing due to their obvious plasticity. If macrophages fail to express specific functions in a timely manner, it will affect the healing function of tissues and lead to pathological tissue healing. Therefore, it is of great significance to understand the different functions of different types of macrophages and to regulate them specifically in different stages of wound healing to promote the healing and regeneration of wound tissue. In this paper, we illustrate the different functions of macrophages in the wound and their basic mechanisms, according to the basic process of wound healing, and emphasize the strategies of macrophage regulation that may be applied to clinical treatment in the future.
