Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease Risk among Chinese Adults.

Hui ZHAO; Xia QIU; Hua Zi LI; Jia Jia CUI; Yong Ye SUN

Return

Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease Risk among Chinese Adults.

Author: Hui ZHAO ¹ ; Xia QIU ² ; Hua Zi LI ³ ; Jia Jia CUI ¹ ; Yong Ye SUN ¹
Author Information

1. Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266071, Shandong, China.
2. State Key Laboratory of Bioactive Seaweed Substances, Qingdao Bright moon Seaweed Group Co. Ltd, Qingdao 266400, Shandong, China.
3. Department of Medical Imaging, Haici Hospital Affiliated to Medical College of Qingdao University, Qingdao 266071, Shandong, China.
Publication Type:Journal Article
Keywords: HDL-cholesterol; Inflammation; Nonalcoholic fatty liver disease; Serum uric acid; The UHR index
MeSH: Adult; Humans; Case-Control Studies; Cholesterol, HDL; East Asian People; Non-alcoholic Fatty Liver Disease; Risk Factors; Uric Acid; China
From: Biomedical and Environmental Sciences 2023;36(1):1-9
CountryChina
Language:English
Abstract: OBJECTIVE:The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio (UHR) and the risk of nonalcoholic fatty liver disease (NAFLD) in Chinese adults.
METHODS:A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD risk.
RESULTS:The multivariable adjusted odds ratio (95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888 (2.324-6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index (BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m². Our dose-response analysis indicated a linear positive correlation between UHR and the risk of NAFLD.
CONCLUSION:UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.