Research progress on the relationship between periodontal pathogens and colorectal cancer
10.12016/j.issn.2096-1456.2023.07.009
- Author:
XIAN Wenpan
1
;
REN Biao
2
;
CHENG Lei
1
Author Information
1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases &Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
Fusobacterium nucleatum;
Porphyromonas gingivalis;
periodontitis;
colorectal cancer;
tumorigenesis;
immune escape;
tumor microenvironment;
tumor prognosis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(7):513-517
- CountryChina
- Language:Chinese
-
Abstract:
With the deepening of the research on the relationship between oral microbiota and systemic diseases, researchers have found that periodontitis is closely related to diabetes, cardiovascular disease, digestive system disease and other systemic diseases. Fusobacterium nucleatum (Fn) and Porphyromonas gingivalis (Pg) are common periodontal pathogens, which play a key role in the occurrence and development of periodontitis. At present, it is also found that Fn and Pg are closely related to the occurrence and development of colorectal cancer (CRC). They can affect the occurrence and development of CRC and the therapeutic effect and prognosis of CRC patients through a variety of ways. It can promote tumor cell proliferation by regulating cell division cycle and inhibiting cell apoptosis, inhibit immune cell function to mediate immune escape and tumor metastasis, and create a pro-inflammatory microenvironment suitable for tumor survival. The study of the effect of periodontal pathogens on the occurrence and development of colorectal cancer and its mechanism also allows us to think about new methods, such as vaccine development, immune agents and antibiotic use to better prevent and treat colorectal cancer and improve the prognosis of patients with colorectal cancer.
- Full text:牙周致病菌与结直肠癌关系的研究进展.pdf
