New drug for thyroid-associated ophthalmopathy——Teprotumumab-trbw
10.3980/j.issn.1672-5123.2023.4.14
- VernacularTitle:治疗甲状腺相关眼病新药——Teprotumumab-trbw
- Author:
Min-Min JIANG
1
;
Ping WANG
1
;
Shu-Xun YAN
1
;
Ying WANG
1
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
- Publication Type:Journal Article
- Keywords:
thyroid-associated ophthalmopathy;
Teprotumumab-trbw;
insulin-like growth factor-Ⅰ receptor inhibitor;
drug therapy
- From:
International Eye Science
2023;23(4):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Teprotumumab-trbw,a monoclonal antibody that acts on the insulin growth factor-Ⅰ receptor, was approved in 2020 for the treatment of thyroid-associated ophthalmopathy, but little is known about it in China. It is hoped to provide guidance for clinical use through the review of its molecular structure, pharmacokinetics, therapeutic mechanism, clinical research and safety. It inhibits immune inflammation by blocking thyroid-stimulating hormone receptor /insulin growth factor-Ⅰ receptor crosstalk signaling, so as to reduce the production of hyaluronic acid and inflammatory factors in response. It can also promote the apoptosis of retro-orbital fibroblasts/adipocytes and inhibit the expression of genes related to the synthesis of thyroid hormones, thereby significantly improving the clinical symptoms such as exophthalmos and diplopia. The common adverse reactions of Teprotumumab-trbw are muscle spasm, hyperglycemia, hearing loss and so on. Teprotumumab-trbw is effective and durable in the treatment of thyroid-associated ophthalmopathy, and patients with secondary treatment can also benefit from it, which provides a new way and hope for the treatment of thyroid-associated ophthalmopathy.
