Exploring the safe and rational use of Epimedii Folium based on the evolution of efficacy/toxicity records in ancient and modern literature

VernacularTitle:从古今文献效/毒记载演变探讨中药淫羊藿安全合理用药
Author: Yuan GAO ¹ ; Jia-bo WANG ¹ ; Xiao-he XIAO ² ; Zhao-fang BAI ²
Author Information

1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
2. China Military Institute of Chinese Medicine, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China; Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China
Publication Type:Research Article
Keywords: Epimedii Folium; toxicity; security; isease-syndrome-based toxicology; the rational use of drugs
From: Acta Pharmaceutica Sinica 2023;58(2):246-257
CountryChina
Language:Chinese
Abstract: Epimedii Folium is a traditional non-toxic Chinese herbal medicine. However, liver injury caused by Chinese herb preparations, including Epimedii Folium, is frequently reported over the years. Based on ancient and modern literature, this paper systematically summarized and analyzed the safe application of Epimedii Folium from the perspectives of varieties, processing methods, clinical adverse reactions, pharmacological effects and toxic mechanism. Combined with our team work, we build the comprehensive prevention and control system "human-drug-application", for the safe and rational application of Epimedii Folium. This study is expected to provide support for scientific evaluation and precise prevention and control of the safety risk of Epimedii Folium.