Survival of Non-small Cell Lung Cancer Patients Treated with Fuzheng Gushe Therapy： A Real World Study
10.13422/j.cnki.syfjx.20231498
- VernacularTitle:基于真实世界的扶正固摄法治疗非小细胞肺癌患者生存分析
- Author:
Tao YANG
1
;
Zhong LI
2
;
Lizheng HAO
3
;
Jian CHEN
4
;
Xueying ZHU
5
;
Min JIANG
1
Author Information
1. Beijing Shijitan Hospital， Capital Medical University， Beijing 100038， China
2. Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China
3. PLA Air Force Characteristic Medical Center， Beijing 100142， China
4. China Rehabilitation Research Center （Beijing Bo'ai Hospital）， Beijing 100068， China
5. First Clinical Medical College， Beijing University of Chinese Medicine， Beijing 100700， China
- Publication Type:Journal Article
- Keywords:
real world study;
non-small cell lung cancer;
propensity score matching;
Fuzheng Gushe therapy;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(9):188-195
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the long-term survival of non-small cell lung cancer （NSCLC） patients treated with Fuzheng Gushe therapy in the real world. MethodA retrospective cohort study was carried out with the NSCLC patients treated with Fuzheng Gushe therapy from January 2014 to December 2018 in Dongzhimen Hospital， Beijing University of Chinese Medicine as the integrated traditional Chinese medicine （TCM） and western medicine cohort. The NSCLC data from January 2011 to December 2015 in the Surveillance， Epidemiology， and End Results （SEER） database were downloaded as the western medicine cohort. The propensity score matching （PSM） was employed to balance the confounding factors between the groups， and comparable samples were obtained from the two groups. The Log-rank test was conducted to compare the overall survival between the groups and the survival curves were established. ResultThe integrated TCM and western medicine cohort and the western medicine cohort included 511 and 5 022 NSCLC patients， respectively. The age， sex， and chemotherapy had no significant differences between the two cohorts， while pathological type， lymph node metastasis （N）， distant metastasis （M）， surgery， and radiotherapy were different between the two cohorts （P<0.05）. After PSM， 122 comparable samples were obtained. The overall survival analysis showed that the total survival of the integrated TCM and western medicine cohort was better than that of the western medicine cohort （P<0.05）. The stratified survival analysis showed that the integrated TCM and western medicine cohort had survival advantages in females， males， the young， and adenocarcinoma， N+， and M+ patients （P<0.05）. ConclusionFuzheng Gushe therapy can significantly improve the overall survival of NSCLC patients， especially in the females， the males， the young， and the patients with adenocarcinoma， lymph node metastasis， and distant metastasis.
