Short chain fatty acid: a messenger of gut-organ axis for disease regulation
10.16438/j.0513-4870.2022-1134
- VernacularTitle:短链脂肪酸: 肠-器官轴调控疾病的信号使者
- Author:
Hui-hui GUO
1
;
Hao-ran SHEN
1
;
Yan-xing HAN
1
;
Jian-dong JIANG
2
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
short chain fatty acid;
gut-organ axis;
gut microbiota;
immuno-inflammation;
endocrine;
signal transduction
- From:
Acta Pharmaceutica Sinica
2023;58(3):593-604
- CountryChina
- Language:Chinese
-
Abstract:
Gut microbiota is a complex and dynamic system, and is essential for the health of the body. As the "second genome" of the body, it can establish communication with the important organs by regulating intestinal nerves, gastrointestinal hormones, intestinal barrier, immunity and metabolism, thus affecting host′s physiological functions. Short chain fatty acid (SCFA), known as one important metabolite of intestinal microbiota, is regarded as a significant messenger of the gut-organ communication, due to its extensive regulation in the body′s immunity, metabolism, endocrine and signal transduction. In this review, we summarize the interaction between gut-liver/brain/kidney/lung axis and diseases, and focus on the role and mechanism of SCFA in the gut-organ communication, hoping to provide new ideas for the treatment of the related diseases.
