A new germacrene-type sesquiterpenoid from Elephantopus tomentosus L.
10.16438/j.0513-4870.2022-1069
- VernacularTitle:白花地胆草中一个新的吉玛烷型倍半萜
- Author:
Meng-yao ZHANG
1
;
Qiang HUANG
2
;
Hai-xin ZHANG
3
;
Meng YU
3
;
Tao ZHANG
3
;
Zhong-mei ZOU
1
Author Information
1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; Shenyang Pharmaceutical University, Shenyang 110016, China
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
- Publication Type:Research Article
- Keywords:
Compositae;
italic>Elephantopus tomentosus L.;
chemical constituent;
germacrene-type sesquiterpenoid;
cytotoxicity
- From:
Acta Pharmaceutica Sinica
2023;58(3):729-735
- CountryChina
- Language:Chinese
-
Abstract:
Fifteen compounds were isolated from the 95% ethanol extract of the whole plant of Elephantopus tomentosus L. by silica gel column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography and semi-preparative HPLC methods. Their structures were identified on the basis of physicochemical properties, and spectral data (UV, IR, NMR, MS and CD) analysis as tomenlephanlide A (1), molephantinin (2), molephantin (3), 8-O-methacryloylelephanpane (4), apigenin (5), tricin (6), 2-phenyl acetamide (7), 3,4-dihydroxybenzoic acid methyl ester (8), caffeic acid methyl ester (9), caffeic acid ethyl ester (10), (+)-(4S)-(2E)-4-hydroxy-2-nonenoic acid (11), E-4-hydroxyhex-2-enoic acid (12), 1H-indole-3-carboxylic acid (13), 1H-indole-3-carbaldehyde (14) and isohematinic acid (15). Among them, compound 1 is a new germacrene-type sesquiterpenoid, 5-15 were obtained from E. tomentosus L. for the first time. It was the first time the absolute configuration of compound 2 was reported. Compound 1 showed weak cytotoxicity against gastric cancer cells (SGC-7901).
