Effect and significance of viral proteins regulating activity of retroelement long interspersed element 1
- VernacularTitle:病毒蛋白调控逆转录元件Ⅰ型长弥散核元件活性的影响及其意义
- Author:
ZHAO Zi⁃han
1
;
WANG Yu
;
ZHAO Yi⁃fei
;
ZHAO Ke
Author Information
- Publication Type:Journal Article
- Keywords: Long interspersed element⁃1（LINE⁃1）；Nef；Vpr；Vpx；HBx
- From: Chinese Journal of Biologicals 2023;36(1):98-104
- CountryChina
- Language:Chinese
- Abstract: Abstract：Long interspersed element⁃1（LINE⁃1）is the only known active and autonomously transposable retroelement in human cells，which is related to autoimmune diseases and plays important roles in activating and regulating the antiviral innate immunity of cells，especially the level of interferon（IFN）. This paper reviews the mechanisms of several non ⁃ structural proteins from human immunodeficiency virus（HIV），hepatitis B virus（HBV）and other viruses participating in the regulation of LINE ⁃ 1 activity. These mechanisms not only ensure the normal expression of viral genome，but also participate in the cellular innate immunity regulation，the inhibition of which may provide new strategies to develop treatments of diseases caused by viruses.
- Full text:病毒蛋白调控逆转录元件Ⅰ型长弥散核元件活性的影响及其意义.pdf
