Liver graft preservation and functional maintenance accelerate the development of liver transplantation
10.3969/j.issn.1674-7445.2023.02.004
- VernacularTitle:供肝保存与功能维护助力肝移植发展
- Author:
Yan XIE
1
;
Wentao JIANG
Author Information
1. Department of Liver Transplantation, Tianjin First Center Hospital, Tianjin Key Laboratory for Organ Transplantation, Research Institute of Transplant Medicine, Nankai University, Tianjin 300190, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Marginal liver graft;
Static cold storage;
Machine perfusion;
Ischemia-reperfusion injury;
Functional maintenance;
Gene therapy;
Stem cell therapy
- From:
Organ Transplantation
2023;14(2):201-
- CountryChina
- Language:Chinese
-
Abstract:
As an effective treatment for end-stage liver disease, liver transplantation has been widely carried out worldwide and gradually captivated widespread recognition. With the advancement of liver transplantation techniques, the incidence of postoperative complications has been gradually declined, and the short-term and long-term prognosis of recipients have been constantly improved. However, a huge gap has existed between the supply and demand of donor organs, which is a major factors restricting the development of liver transplantation. The amount of liver transplantation operation in China is increasing year by year, the shortage of donor liver is becoming more and more prominent, and marginal donor liver is increasingly used in clinic. In recent years, the selection criteria of donor organs, organ preservation and functional maintenance have been continuously improved. In this article, the application and development trend of different techniques were reviewed from the perspectives of donor liver preservation and functional maintenance, and recent technical development and research results were summarized, aiming to provide reference for further enhancing the survival rate of grafts and recipients and promoting the development of liver transplantation in China.
