Advances in the Proteomics Research on Neuropathic Pain (review)
- VernacularTitle:神经病理性疼痛的蛋白质组学研究进展
- Author:
Xuanying LI
- Publication Type:Journal Article
- Keywords:
neuropathic pain, proteomics, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(4):341-344
- CountryChina
- Language:Chinese
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Abstract:
Neuropathic pain is an intractable pain condition that initiated or caused by a primary lesion or dysfunction in the nervous system. Because the underlying molecular mechanisms of neuropathic pain are largely unknown, routine pharmacologic treatment is often insufficient. It has become a rather tough problem bothering both physicians and patients. Recently, with the development of molecular biology, the study of neuropathic pain stepped into the post-genomic period which is characterized by study of proteome. A number of proteomic studies have been performed using different animal neuropathy models. The Results of these proteomic approaches are summarized in this review to provide a better overview of proteins that are involved in the mechanisms of neuropathic pain. This might allow a better understanding of the pathogenesis of neuropathic pain, and facilitate the discovery of specific therapies and new treatment target.
