Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity
- VernacularTitle:山茱萸果实化学成分及其抗阿尔茨海默症活性研究
- Author:
Meng YANG
1
;
Zhi-you HAO
1
;
Shi-qi ZHOU
1
;
Bing CAO
1
;
Deng-hui ZHU
1
;
Ying YANG
1
;
Jun-jun WEI
1
;
Si-qi TAO
1
;
Bo-wen ZHANG
1
;
Xiao-ke ZHENG
1
;
Wei-sheng FENG
1
Author Information
- Publication Type:Research Article
- Keywords: italic>Cornus officinalis; chemical constituent; lignan glycoside; neolignan A; anti-Alzheimer's disease activity
- From: Acta Pharmaceutica Sinica 2022;57(12):3608-3615
- CountryChina
- Language:Chinese
-
Abstract:
Fifteen compounds were isolated from fruits of
Cornus officinalis by various chromatographic techniques such as Toyopearl HW-40C, Sephadex LH-20, silica gel, and the semi-preparative HPLC. Their chemical structures were identified by analysis of physicochemical properties and spectral data, and determined as neolignan A (1 ), caffeic acid (2 ),trans -p -hydroxy cinnamic acid (3 ), esculetin (4 ), scopoletin (5 ), benzyl-7-O -β -D -glucopyranoside (6 ), tachioside (7 ), 6-O- (4-hydroxybenzoyl) arbutin (8 ), 2-(3′,4′-dihydroxyphenyl)-1,3-benzodioxole-5-carboxaldehyde (9 ), (-)-pinoresinol-4-O -β -D -glucopyranoside (10 ), (7S ,8R )-dihydrodehydrodiconiferyl alcohol-9-O -β -D -glucopyranoside (11 ), (7S ,8R )-dihydrodehydrodiconiferyl alcohol-9′-O -β -D -glucopyranoside (12 ), (+)-lyoniresinol (13 ), (+)-isolariciresinol-9-O -β -D -glucopyranoside (14 ), and isolariciresinol-9′-O -β -D -glucopyranoside (15 ). Compound1 was a new compound and named as neolignan A, and compounds6 -9 and14 were isolated fromCornus officinalis for the first time. Compounds2 ,3 and15 efficiently alleviated the PC12 cells injury induced by Aβ 25-35, suggesting their potential anti-Alzheimer's disease activity.
