A novel sesquiterpenoid from Curcuma longa L.
10.16438/j.0513-4870.2022-0702
- VernacularTitle:姜黄中一个新颖的倍半萜成分
- Author:
Bo-yu LI
1
;
Cheng PENG
2
;
Hong-zhen SHU
1
;
Fei LIU
1
;
Liang XIONG
1
Author Information
1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
- Publication Type:Research Article
- Keywords:
italic>Curcuma longa L.;
isolation and identification;
new compound;
absolute configuration;
sesquiterpenoid
- From:
Acta Pharmaceutica Sinica
2022;57(12):3603-3607
- CountryChina
- Language:Chinese
-
Abstract:
A new compound was isolated from the 95% ethanolic extract of the rhizomes of Curcuma longa L. using silica gel column chromatography, medium pressure liquid chromatography, and semi-preparative high performance liquid chromatography. The structure and absolute configuration of the compound was elucidated by HR-ESI-MS, NMR, and electronic circular dichroism (ECD) calculations. It is a novel sesquiterpenoid, which is named as isoturmeronol B (1). The carbon skeleton of compound 1 is similar to that of bisabolane-type sesquiterpenoid. The only difference is that the methyl group at C-4 in bisabolene-type sesquiterpenoid is migrated to C-5 in compound 1. Besides, the anti-inflammatory and antioxidant activities of the compound 1 were evaluated. The results showed that 1 has no anti-inflammatory and antioxidant activities.
