Research progress of cell membrane-coated biomimetic nanoparticle delivery systems for the treatment of lung diseases
10.16438/j.0513-4870.2022-0559
- VernacularTitle:用于肺部疾病治疗的细胞膜涂层仿生纳米粒递送体系研究进展
- Author:
Yu-ying WANG
1
;
Xi WANG
1
;
Hong-lin QIN
1
;
Jian YANG
2
Author Information
1. State Key Laboratory of Component-based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. State Key Laboratory of Component-based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
- Publication Type:Research Article
- Keywords:
cell membrane coated;
biomimetic nanoparticle;
rug delivery system;
pulmonary disease;
physiological barrier;
immune escape
- From:
Acta Pharmaceutica Sinica
2023;58(1):76-85
- CountryChina
- Language:Chinese
-
Abstract:
Lung is susceptible to external disturbance, resulting in a variety of acute and chronic lung diseases. Functionalized nanoparticles as carriers can carry drugs through multiple biological barriers of lung into lung lesions, but there are some problems such as poor targeting and low therapeutic efficiency. As a drug carrier, membrane-coated biomimetic nanoparticles have the characteristics of immune system escape, active targeting, inflammatory chemotaxis and crossing physiological barriers due to the retention of the characteristics of the source cells. Therefore, it has been widely used in the treatment of lung diseases in recent years. In this review, the application of membrane-coated biomimetic nanoparticles in the treatment of lung diseases in the recent years was summarized and classified. Cell membrane sources include erythrocyte membrane, platelet membrane, macrophage membrane, neutrophil membrane, lung epithelial membrane, lung surfactant, endothelial membrane, cancer cell membrane, bacterial membrane, hybrid membrane and so on. The purpose of this review is to provide a new idea for treating lung diseases with membrane-coated biomimetic nanoparticles.
