Advances in experimental myopic guinea pig models
10.3980/j.issn.1672-5123.2023.3.16
- VernacularTitle:实验性近视豚鼠模型研究进展
- Author:
Gui-Mei ZHOU
1
;
Chang-Jun LAN
1
;
Xuan LIAO
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China; Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
myopia;
guinea pig;
animal model;
histomorphology
- From:
International Eye Science
2023;23(3):430-434
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of myopia is increasing year by year, seriously affecting the public's quality of life. To date, various animal models of myopia have been established to explore the pathogenesis of myopia. Guinea pigs have obvious advantages in myopia research. At present, guinea pigs are the most common myopia animal model in Asian laboratories, but different modeling methods have their own advantages and disadvantages. Understanding different modeling methods is conducive to selecting appropriate animal models and matching different research purposes, which makes the research results more persuasive. In this paper, the different modeling methods and characteristics of guinea pig myopia model in recent years, as well as the changes of ocular histomorphology in guinea pigs are briefly reviewed, with a view to providing some reference for further study of the molecular mechanism of myopia occurrence and development and finding new treatment strategies.
