Application and prospect of gene therapy for fundus vascular diseases
10.3980/j.issn.1672-5123.2023.3.10
- VernacularTitle:基因治疗在眼底血管性疾病中的应用和展望
- Author:
Chao-Yang ZHANG
1
;
Jing-Xiang ZHANG
1
;
Jing-Fa ZHANG
1
Author Information
1. Department of Ophthalmology, Shanghai General Hospital;National Clinical Research Center for Eye Diseases;Shanghai Key Laboratory of Ocular Fundus Diseases;Shanghai Engineering Center for Visual Science and Photomedicine;Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China
- Publication Type:Journal Article
- Keywords:
gene therapy;
fundus vascular diseases;
neovascular age-related macular degeneration;
diabetic retinopathy;
diabetic macular edema;
anti-vascular endothelial growth factor
- From:
International Eye Science
2023;23(3):400-406
- CountryChina
- Language:Chinese
-
Abstract:
Fundus vascular diseases, including neovascular age-related macular degeneration(nAMD)and diabetic retinopathy(DR), are the leading causes of visual impairment worldwide. With the accelerated aging and increased incidence of diabetes, the prevalence of these two fundus diseases will continue to rise. Currently, intraocular injection of anti-vascular endothelial growth factor(anti-VEGF)remains the first-line treatment for fundus vascular diseases, but disadvantages exist, such as frequent intraocular injections, high cost and poor compliance, thus more durable and effective therapeutic strategies need to be explored. The successful application of gene therapy in inherited retinal diseases(IRDs)provides a new idea for the treatment of fundus vascular diseases. With the ongoing of several clinical trials, gene therapy for fundus vascular diseases is expected to be employed in the clinical setting. But there still remain some concerns, including the optimal therapeutic targets selection, administration route and safety issues. This review focuses on the application and prospect of gene augmentation and gene editing-mediated anti-VEGF therapy for the treatment of nAMD and DR.
