Hepatorenal Syndrome.
10.3904/kjm.2016.90.5.384
- Author:
Jung Pyo LEE
1
Author Information
1. Division of Nephrology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. nephrolee@gmail.com
- Publication Type:Review
- Keywords:
Hepatorenal syndrome;
Cirrhosis;
Renal failure;
Transplantation;
Terlipressin
- MeSH:
Blood Vessels;
Fibrosis;
Glomerular Filtration Rate;
Hepatorenal Syndrome*;
Humans;
Hypertension, Portal;
Liver Diseases;
Liver Failure, Acute;
Liver Transplantation;
Renal Insufficiency;
Transplantation;
Vasoconstriction;
Vasopressins
- From:Korean Journal of Medicine
2016;90(5):384-388
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatorenal syndrome is a functional renal failure occurred in end-stage liver disease. It is regarded as one of the most serious complications of liver disease; commonly occur in patients with cirrhosis or acute liver failure. Pathophysiologically, portal hypertension induced vasoconstriction in the renal cortex reduces glomerular filtration rate. There are no intrinsic renal diseases or histological abnormalities. In most patients, the natural course of the renal failure leads to fatal consequences, even though various treatment options have been provided. Liver transplantation and combination therapy of albumin and vasopressin analogs can restore the damage of the blood vessel.
