The Effect of Narrowband Ultraviolet B Phototherapy on Vitamin D Status in Psoriasis Patients with Skin Phototype III, IV and V
- Author:
Rani Manohari Kuppusamy
1
;
Adawiyah Jamil
2
;
Nazatul Shima
1
Author Information
- Publication Type:Journal Article
- Keywords: 25-hydroxyvitamin D; Fitzpatrick skin phototype; Psoriasis; Narrowband Ultraviolet-B; Phototherapy
- MeSH: Psoriasis; Phototherapy; Vitamin D
- From:Malaysian Journal of Dermatology 2021;47(Dec 2021):63-69
- CountryMalaysia
- Language:English
-
Abstract:
Background:Narrowband ultraviolet-B (NBUVB) is an effective treatment option for psoriasis. Vitamin D
insufficiency is common in psoriasis patients. We assessed the effect of NBUVB on vitamin D levels
amongst psoriasis patients with skin phototype III, IV and V.
Methods:Psoriasis patients planned for NBUVB phototherapy were enrolled in a prospective cohort study in Hospital Putrajaya and Hospital Kuala Lumpur from May 2020-December 2020. NBUVB phototherapy was given twice weekly for 12 weeks. Serum 25 (OH)D level was measured at baseline and at week 12.
Results:A total of 21(63.6%) male and 12(36.4%) female patients aged 18-66 years participated. Majority were Fitzpatrick skin phototype (FSP) IV (66.7%) followed by FSP V (21.2%) and FSP III (12.1%). Serum 25(OH)D increased significantly (p<0.001) from 52.09±21.43 nmol/L at baseline to 72.80±19.56 nmol/L at week 12 with the most increment seen in skin type V. There was also a significant improvement seen in Body Surface Area (BSA) involvement after 12 weeks of phototherapy (p<0.001). There was no correlation seen between BSA at week 12 with serum 25(OH)D and percentage of serum 25(OH) D increment.
Conclusion:NBUVB phototherapy increases the level of serum 25(OH)D in psoriasis patients with darker skin types while simultaneously clearing psoriasis. - Full text:15.2021my0019.pdf
