Effects of Physical Heterogeneity Variation on Differentiation Potential of Mesenchymal Stem Cells During Senescence
10.16156/j.1004-7220.2022.03.30
- VernacularTitle:衰老过程中间充质干细胞物理异质性变化对分化潜能的影响
- Author:
Yao WANG
1
;
Xiaobo GONG
2
;
Zhifeng YU
1
Author Information
1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedics,Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
2. School of Naval Architecture, Ocean & Civil Engineering, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
senescence;
physical heterogeneity;
mesenchymal stem cells (MSCs);
cell size;
cell stiffness;
nucleoplasmic ratio
- From:
Journal of Medical Biomechanics
2022;37(3):E575-E580
- CountryChina
- Language:Chinese
-
Abstract:
With the multi-directional differentiation potential such as osteogenic differentiation, chondrogenic differentiation and adipogenic differentiation, mesenchymal stem cells (MSCs) have been widely used in basic research and clinical applications. The differentiation potential of MSCs is altered during senescence. Osteogenic differentiation potential decreases, while the lipogenic differentiation potential increases in aging MSCs. Changes in differentiation potential of MSCs during senescence are accompanied with cell physical heterogeneity variation (cell size, cell stiffness and nucleoplasmic ratio). Studies have shown that changes in physical heterogeneity of stem cells may be a key factor leading to the differences in differentiation potential of MSCs. Therefore, studies on physical heterogeneity variation of MSCs during senescence will provide a new research direction in fate prediction of stem cell. In this review, the effects of physical heterogeneity variation on differentiation potential of MSCs were summarized, and the corresponding mechanism was also discussed.
