Effect of Combination of Baclofen, Tizanidine and Eperisone on Moderate to Severe Spasticity after Spinal Cord Injury

VernacularTitle:联合用药治疗脊髓损伤中重度痉挛的临床观察
Author: Genlin LIU ; Hongjun ZHOU ; Jianjun LI ; Ying ZHENG ; Chunxia HAO ; Ying ZHANG ; Bo WEI ; Yiji WANG ; Haiqiong KANG ; Jiazong WANG
Publication Type:Journal Article
Keywords: spinal cord injury, spasticity, baclofen, tizanidine, eperisone, rehabilitation
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(11):1080-1081
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of combination of baclofen, tizanidine and eperisone on moderate or severe spasticity after spinal cord injury. Methods 18 inpatients with moderate (n=2) or severe (n=16) spasticity after spinal cord injury were treated with combination of 2 or 3 kinds of drugs for 2 months, and followed up for at least 4 months with modified Ashworth scale (MAS). Their blood pressure, blood and urine routine, liver and kidney function were observed. Results Among the 16 cases of severe spasticity (MAS≥3), MAS reduced 3 grades in 3 cases, 2 grades in 12 cases, 1 grade in 1 case, with alleviation of phantom pain. For the cases of moderate spasticity (MAS=2), the MAS reduced 1 grade with alleviation of phantom pain. Slightly drowsiness was observed in 2 cases. No hepatic or renal dysfunctions was found. Conclusion Combination of baclofen, tizanidine and eperisone is effective on moderate or severe spasticity after spinal cord injury with limited side-effects.