Clinical characteristics and survival of patients with HIV/AIDS and pulmonary tuberculosis
10.3969/j.issn.1006-2483.2023.01.037
- VernacularTitle:HIV/AIDS合并肺结核患者临床特征及生存情况调查分析
- Author:
Ying-ying ZHANG
1
;
Dong-rui ZHENG
2
;
Min YAN
3
Author Information
1. Department of Infectious Diseases , Deyang People's Hospital , Deyang , Sichuan 618000 , China
2. Department of Intensive Medicine , Deyang People's Hospital , Deyang , Sichuan 618000 , China
3. Department of Intervention , Deyang People's Hospital , Deyang , Sichuan 618000 , China
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Acquired immunodeficiency syndrome;
Pulmonary tuberculosis;
CD4 cell;
Survival
- From:
Journal of Public Health and Preventive Medicine
2023;34(1):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of patients with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) and pulmonary tuberculosis, and investigate their survival and influencing factors of survival. Methods A total of 107 patients with HIV/AIDS and pulmonary tuberculosis were selected. The relationships of clinical symptoms, CT findings and CD4 cell count with positive laboratory tests were analyzed. Th survival of patients was investigated, and independent risk factors for death were analyzed. Results Most the 107 patients had symptoms such as cough, chest pain and fatigue. CT findings mainly included patchy shadow (75.70%), tree-in-bud sign (46.73%), nodular shadow (35.51%) and pulmonary hilar or mediastinal lymph node enlargement (86.92%). The proportion of lesions ≥ 3 pulmonary fields (47.66%) was higher. The positive rates of purified protein derivative (PPD), acid-fast bacilli and Mycobacterium tuberculosis were significantly higher in the CD4 cell count > 200/µL group than in the ≤200/µL group (P<0.05). There were statistically significant differences in body mass index (BMI), baseline CD4 cell count, multidrug resistant tuberculosis (MDR-TB) and standard anti-tuberculosis treatment between the survival group and the death group (P<0.05). Baseline CD4 cell count ≤200/µL, MDR-TB, and no standard anti-tuberculosis treatment were independent risk factors for death of patients with HIV/AIDS and pulmonary tuberculosis (P<0.05). Conclusion The clinical symptoms and imaging manifestations of patients with HIV/AIDS and pulmonary tuberculosis are complex and diverse, but characteristic. Baseline CD4 cell count ≤200/µL, MDR-TB and no standard anti-tuberculosis treatment are main risk factors for death of the patients.
