Correlation analysis of hepatic steatosis, blood lipids and uric acid metabolism in elderly patients with chronic hepatitis B
10.3969/j.issn.1006-2483.2023.01.035
- VernacularTitle:老年慢性乙型肝炎患者肝脂肪变性与血脂、尿酸代谢的相关性分析
- Author:
Yuan-ying YIN
1
;
Di XIA
1
;
Jiang-rong QIAO
1
;
Hong-fei REN
1
;
Ming-guang ZHANG
1
Author Information
1. Department of Gastroenterology , West China Hospital , Sichuan University , Chengdu , Sichuan 610041 , China
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Hepatic steatosis;
Blood lipid;
Uric acid
- From:
Journal of Public Health and Preventive Medicine
2023;34(1):144-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation of hepatic steatosis with blood lipids and uric acid metabolism in elderly patients with chronic hepatitis B (CHB). Methods The clinical data of 120 patients with CHB admitted to the hospital from January to December 2021 were retrospectively analyzed. According to the presence or absence of hepatic steatosis, the patients were divided into steatosis group (n=35) and non-steatosis group (n=85). The general clinical data, serological indicators of hepatitis B virus, blood lipid and uric acid levels were compared between the two groups. The correlation of hepatic steatosis grading with blood lipids and uric acid metabolism was analyzed. Results The inflammation and fibrosis degree of liver tissues were significantly different in the two groups (P<0.05). The levels of TG and TC in the steatosis group were higher than those in the non-steatosis group, and the level of HDL-C was lower than that in the non-steatosis group (P<0.05). There was no significant difference between the two groups in LDL-C and uric acid levels (P>0.05). Pearson correlation analysis found that the grade of hepatic steatosis in patients with CHB was negatively correlated with liver tissue inflammation, fibrosis degree and HDL-C level (P<0.05), and positively correlated with TG and TC levels (P<0.05). Conclusion Elderly patients with CHB and hepatic steatosis have abnormal blood lipid metabolism. Hepatic steatosis will exacerbate abnormal blood lipid metabolism but not liver tissue inflammation or fibrosis degree. Clinically, attention should be paid to blood lipid monitoring of elderly patients with CHB.
