Correlation of serum creatinine, blood urea nitrogen and uric acid levels in patients with nephrotic syndrome
10.3969/j.issn.1006-2483.2023.01.026
- VernacularTitle:成年肾病综合征患者血清肌酐、尿素氮与尿酸水平的关联分析
- Author:
Hong ZHANG
1
;
Chuan DENG
1
;
Jia-zhen YU
1
;
Xue-li CUI
1
Author Information
1. Department of Laboratory , Nanchong Central Hospital , Nanchong , Sichuan 637000 , China
- Publication Type:Journal Article
- Keywords:
Aadults;
Nephrotic syndrome;
Creatinine;
Urea nitrogen;
Uric acid
- From:
Journal of Public Health and Preventive Medicine
2023;34(1):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum creatinine, blood urea nitrogen content and uric acid level in adult nephrotie syndrome (AS) patients of different ages, in order to provide a theoretical basis for the prevention and control of uric acid metabolism. Methods Individuals of different ages who were diagnosed with nephrotic syndrome from March 2018 to August 2020 in the outpatient department of our hospital were selected as research subjects by stratified random sampling,healthy individuals who underwent physical examination during the same period were selected as controls .The age range of the subjects was 18-55 years old. The biochemical test results of serum creatinine, blood urea nitrogen and uric acid were retrospectively collected from patients of different ages. Pearson correlation analysis of adult serum creatinine, blood urea nitrogen and uric acid levels. Results The levels of creatinine and blood urea nitrogen in healthy adults showed an upward trend at the age of 18-40, and reached a plateau at the age of 40; while the level of uric acid showed an upward trend with age. The levels of serum creatinine, blood urea nitrogen and uric acid in AS patients at different ages were higher than those in healthy controls, and the increase was most pronounced between the ages of 45 and 55. The t-test results showed that the serum creatinine, blood urea nitrogen and uric acid contents of healthy controls were different from those of AS patients except for the 18-22 age group. The main performance was that AS patients had higher measured values than healthy controls. Pearson correlation was used to analyze the correlation between serum creatinine and blood urea nitrogen levels and uric acid in AS patients of different ages. The results showed that the 41-45-year-old patients had the strongest correlation with uric acid, r was 0.584; The patients' blood urea nitrogen level had the strongest correlation with uric acid, with r of 0.373. The age groups with the correlation between serum creatinine, blood urea nitrogen and uric acid content in AS patients were stratified according to gender. There was a significant positive correlation (r>0.45, P<0.05); at the same time, there was a certain correlation between blood urea nitrogen and uric acid levels in female AS patients aged 21-25 and 51-55 (r>0.30, P<0.05). Conclusion The expression level of serum creatinine in 34-45 years old patients with nephrotic syndrome can effectively predict the level of uric acid, and the predictive value of women is higher than that of men.
