Research progress on the relationship between serum uric acid and sarcopenia
10.3969/j.issn.1006-2483.2023.01.002
- VernacularTitle:血尿酸与骨骼肌减少症关系的研究进展
- Author:
Yu-yang LIU
1
;
Yi-zi LIU
1
;
Qi-jun WU
1
;
Yu-hong ZHAO
1
Author Information
1. Department of Clinical Epidemiology, Shengjing Hospital , China Medical University , Shenyang , Liaoning 110004 , China;Clinical Research Center , Shengjing Hospital , China Medical University , Shenyang , Liaoning 110004 , China;Key Laboratory of Precision Medical Research on Major Chronic Disease , Liaoning Province , Shenyang , Liaoning 110004 , China
- Publication Type:Journal Article
- Keywords:
Serum uric acid;
Sarcopenia;
Oxidative stress
- From:
Journal of Public Health and Preventive Medicine
2023;34(1):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective With the deepening of population aging, sarcopenia has become an important public health problem affecting the health and quality of life of the elderly population. As the end-product of purine metabolism in human body, uric acid has dual effects of anti-oxidation, pro-oxidation and pro-inflammatory reaction , which affects the occurrence and development of sarcopenia to a certain extent. This paper reviews the research progress of serum uric acid and sarcopenia. Methods PubMed database, Web of Science core collection database, Embase database, China National Knowledge Infrastructure (CNKI) and Wanfang database were searched for literatures on the relationship between serum uric acid (SUA) level and sarcopenia up to February 7, 2022, and then reviewed. Results A total of 4 epidemiological studies were found on serum uric acid levels and the risk of sarcopenia. Among them, 3 studies found that SUA within a certain level range was a protective factor for sarcopenia, and 1 study suggested that the risk of sarcopenia increased with the increase of SUA levels. There was a gender difference between serum uric acid level and sarcopenia risk. Conclusion At present, the results of studies on the relationship between serum uric acid levels and the risk of sarcopenia are still controversial, which may be caused by the different effects of uric acid in human body. In the future , more extensive and in-depth studies are needed to investigate the relationship between the two.
