Risk factors for early colorectal cancer in patients with dyslipidemia
10.3760/cma.j.cn321463-20220313-00103
- VernacularTitle:血脂异常患者结直肠早期癌发病的危险因素分析
- Author:
Shutong ZHOU
1
;
Shutian ZHANG
Author Information
1. 首都医科大学附属北京友谊医院消化分中心 国家消化系统疾病临床医学研究中心 北京市消化疾病中心 消化疾病癌前病变北京市重点实验室，北京 100050
- Keywords:
Dyslipidemias;
Colorectal neoplasms;
Colorectal adenomas;
Risk factors
- From:
Chinese Journal of Digestive Endoscopy
2022;39(7):568-572
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the risk factors for early colorectal cancer in patients with dyslipidemia and the possible role of statins, data of 266 patients with colorectal mass and dyslipidemia who received endoscopic treatment in Beijing Friendship Hospital from February 2018 to February 2021 were collected. The patients were divided into the colorectal adenoma group ( n=174) and the early colorectal cancer group ( n=92) according to colonoscopic and pathological results. Clinical data of the two groups were analyzed. Logistic regression analysis was used to evaluate the risk factors for early colorectal cancer in patients with dyslipidemia. The results showed compared with the colorectal adenoma group, the early colorectal cancer group had a higher proportion of males (64.1% VS 25.9%), smoking (41.3% VS 14.4%) and drinking (37.0% VS 17.2%) and higher low density lipoprotein cholesterol (LDL-C) (3.06±0.81 mmol/L VS 2.60±0.74 mmol/L) and total cholesterol (TC) values (5.27±1.22 mmol/L VS 4.61±1.06 mmol/L), while the proportion of statin use was lower (27.2% VS 52.9%). There were significant differences in the above indices (all P<0.05). Multivariate logistic regression analysis showed that male ( OR=3.641, 95% CI:1.694-7.826), smoking ( OR=2.920, 95% CI:1.159-7.356), higher LDL-C ( OR=2.203,95% CI:1.481-3.277) and higher TC level ( OR=1.744,95% CI:1.329-2.289) were risk factors for early colorectal cancer in patients with hyperlipidemia, while the history of statin use ( OR =0.469, 95% CI: 0.236-0.932) had a protective effect. Smoking cessation education, early screening of LDL-C, TC level, statin use if necessary to reach the standard lipids and screening of early colorectal cancer should be actively carried out in patients with dyslipidemia.
