Association of glucose metabolism with adverse pregnancy outcomes in pregnant women of Chongming area
10.3760/cma.j.cn311282-20220302-00125
- VernacularTitle:崇明地区妊娠期妇女糖代谢状况及与妊娠不良结局的相关性研究
- Author:
Yin XING
1
;
Hongxia GU
;
Yuli HUANG
;
Hui HUANG
;
Yiming WU
;
Li QIN
Author Information
1. 上海交通大学医学院附属新华医院崇明分院内分泌科 202150
- Keywords:
Gestational diabetes mellitus;
Blood glucose;
Metabolic status;
Adverse pregnancy outcomes
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(10):848-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of hyperglycemia during pregnancy and its correlation with adverse pregnancy outcomes based on the retrospective analysis of glucose metabolism of pregnant women in Chongming area.Methods:A total of 604 singleton pregnant women who underwent prenatal examination and delivered normally in the Chongming branch of Xinhua Hospital from September 2019 to May 2021 were enrolled in the study. All subjects were divided into normal glucose tolerance gestation (NGTG) group and gestational diabetes mellitus (GDM) group. Pregnant women whose blood glucose exceeded normal but did not meet the diagnostic criteria of GDM were classified into the intermediate state gestational blood glucose (ISGBG) group. Questionnaire, physical examination, and relevant laboratory tests were completed. Data were analyzed using the Statistical Product and Service Solutions 13.0 (SPSS, Chicago, IL).Results:The incidence rate of GDM was 20.86% (126/604), ISGBG was 40.39% (244/604), and NGTG was 38.74% (234/604) in 604 pregnant women. Multivariate logistic regression analysis showed that gestational age ( OR=1.092, P<0.001), serum triglyceride ( OR=1.625, P=0.001) and free T 3 levels ( OR=1.995, P=0.002) were independent risk factors for GDM. The incidence of pregnancy-induced hypertension, cesarean section, macrosomia, the total incidence of adverse pregnancy outcomes and fetal birth weight in ISGBG and GDM were significantly higher than those in NGTG ( P<0.05 or P<0.01). Conclusion:The incidence of GDM in Chongming area is high, especially higher in that of ISGBG. As both GDM and ISGBG lead to increased adverse pregnancy outcomes, early monitoring should be paid more attention to pregnant women in ISGBG in addition to the early intervention of GDM.
