Applications of stable isotope metabolic flux analysis in tumor metabolic reprogramming
10.3760/cma.j.cn321828-20210204-00028
- VernacularTitle:稳定同位素代谢流分析在肿瘤代谢重编程中的应用进展
- Author:
Qianyun WU
1
;
Wenzhi JIA
;
Yumei CHEN
;
Jianjun LIU
Author Information
1. 上海交通大学医学院附属仁济医院核医学科，上海 200127
- Keywords:
Metabolic flux analysis;
Isotopes;
Metabolic reprogramming;
Neoplasms;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2022;42(9):563-567
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming is a hallmark of tumors. Tumors own unique metabolic patterns in different stages of their occurrence and development. The stable isotope metabolic flux analysis technology uses stable isotope to trace the metabolites in tumors and crystallize tumor metabolism network. Stable isotope metabolic flux analysis is a useful tool for studying tumor metabolism, which can determine the nutritional sources, find the metabolic liabilities, confirm the metabolic pattern of tumors, and discover new mechanisms of tumor metabolic reprogramming, thus providing theoretical bases for imaging, diagnosis, treatment and evaluation of tumor. This article reviews the applications of stable isotope flux analysis in tumor metabolic reprogramming.
