Research progress on the heterogeneity of hepatocellular carcinoma
	    		
		   		
		   			
		   		
	    	
    	 
    	10.3760/cma.j.cn113884-20220104-00006
   		
        
        	
        		- VernacularTitle:肝细胞癌异质性的研究进展
 
        	
        	
        	
        		- Author:
	        		
		        		
		        		
			        		Yuxin DUAN
			        		
			        		
			        		
			        			1
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Zhongjun WU
			        		
			        		;
		        		
		        		
		        		
			        		Rui LIAO
			        		
			        		
		        		
		        		
		        		
		        		
		        			
			        		
			        		Author Information
			        		
		        		
		        		
			        		
			        		
			        			1. 重庆医科大学附属第一医院肝胆外科,重庆 400042
			        		
		        		
	        		
        		 
        	
        	
        	
        	
        		- Keywords:
        			
	        			
	        				
	        				
			        		
				        		Carcinoma, hepatocellular;
			        		
			        		
			        		
				        		Tumor microenvironment;
			        		
			        		
			        		
				        		Tumor heterogeneity;
			        		
			        		
			        		
				        		Tumor progression
			        		
			        		
	        			
        			
        		
 
        	
            
            
            	- From:
	            		
	            			Chinese Journal of Hepatobiliary Surgery
	            		
	            		 2022;28(11):877-880
	            	
            	
 
            
            
            	- CountryChina
 
            
            
            	- Language:Chinese
 
            
            
            	- 
		        	Abstract:
			       	
			       		
				        
				        	Hepatocellular carcinoma cells interact with tumor microenvironment, and exhibits There are temporal and spatial heterogeneity of hepatocellular carcinoma which interacts with tumor microinvironment. In this paper, we summarized the characteristics of hepatocellular carcinoma heterogeneity, the mechanism of heterogeneity, and the impact of hepatocellular carcinoma heterogeneity on diagnosis and treatment, so as to provide a new thinking direction for the diagnosis and treatment of hepatocellular carcinoma.