Research progress in the effect and mechanism of stem cell-derived exosomes in tendon and enthesis repair

VernacularTitle:干细胞外泌体修复肌腱及腱骨止点的作用及机制研究进展
Author: Yue WANG ¹ ; Chun XIA ; Shaojie WANG
Author Information

1. 厦门大学附属中山医院关节外科与运动医学科，厦门　361001
Keywords: Stem cells; Exosomes; Tendon injuries; Repair
From: Chinese Journal of Trauma 2022;38(6):571-576
CountryChina
Language:Chinese
Abstract: Tendon and enthesis injuries are common sports injuries that seriously impair patients′ daily activities and quality of life. Surgical reconstruction is the main treatment for tendon and enthesis injuries. However, the surgical effect is often unsatisfactory due to the structure of repaired tendon and enthesis remaining different from those of the native ones, and re-rupture is prone to occur. Exosomes are lipid bilayer vesicles containing varieties of active substances, which play a crucial role in the communication of different cells. As a new cell-free therapy, stem cell-derived exosomes have been widely studied in the fields of drug delivery, tissue engineering and degenerative diseases, but their role in tendon and enthesis repair is rarely concerned. Therefore, the authors review tendon and enthesis injuries from aspects of histological features, repair process, and repair effect and mechanism of action of stem cells-derived exosomes, aiming to provide new insights into the basic research and clinical treatment of tendon and enthesis injuries.