Research progress of chronic ethanol consumption on neural circuits of cerebellum and behaviors
10.3760/cma.j.cn371468-20220707-00383
- VernacularTitle:长期酒精摄入对小脑神经环路及行为的影响研究进展
- Author:
Guanglin JIN
1
;
Chengquan LIN
;
Yanji JIN
;
Songbiao CUI
;
Guanghui DONG
Author Information
1. 延边大学附属医院神经内科，延吉 133000
- Keywords:
Ethanol;
Cerebellar cortex;
Neural circuit;
Behavioral functions;
Synaptic transimission;
Synaptic plasticity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(12):1143-1148
- CountryChina
- Language:Chinese
-
Abstract:
Ethanol is one of the most widely used and abused psychoactive substances in the world. Long-term and excessive intake of alcohol can damage the central nervous system and lead to impairment of its function. As an important component of the central nervous system, cerebellum is one of the main target organs damaged by ethanol. Acute and chronic ethanol intake can damage human motor coordination, motor learning and some cognitive functions. Its damage mechanism is generally believed to be caused by the abnormal function of cerebellar cortical neural circuit caused by ethanol intake. Combined with recent studies on the mouse model of long-term ethanol intake, this article reviews the cerebellar neural network mechanism of long-term ethanol intake from various aspects, with a view to providing research and development in behavioral movement, motor coordination, cognitive function, depression, and offers new ideas with the rise of precision medicine for treatment. People are increasingly interested in exploring the mechanism of long-term ethanol intake on the cerebellar neural network. How to improve or block the corresponding mechanism based on the mechanism of action found in existing research is an important proposition in future research.
