Retinal optical coherence tomography and optical coherence tomography angiography in Alzheimer's disease

VernacularTitle:视网膜光相干断层扫描/血管成像技术在阿尔茨海默病中的研究进展
Author: Qinghua ZHANG ¹ ; Wenguang WANG ; Yifeng DU
Author Information

1. 山东第一医科大学附属省立医院神经内科，济南　250021
Keywords: Alzheimer's disease; Retina; OCT/OCTA; Biomarker
From: Chinese Journal of Behavioral Medicine and Brain Science 2022;31(10):955-960
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is the most common cause of dementia. With population aging, AD has become one of the urgent public health problems worldwide. The retina as a " window" to the brain dysfunction. Studies based on optical coherence tomography/ optical coherence tomography angiography(OCT/OCTA) imaging technology have shown that retinal vascular and structure were significantly changed in patients with clinical and preclinical AD. The changes of retinal vascular and structure were also significantly correlated with cognitive scores, cerebral degeneration, and the decline of cognitive function. These findings suggest that ocular structure and vascular changes based on OCT/OCTA imaging can provide non-invasive, inexpensive and practical biomarkers for early diagnosis of AD. This article reviews the research status and limitations of retinal structure and vascular changes in AD based on OCT/OCTA, in order to provide new ideas and methods for early dingnosis of AD.