The interaction between 5-HTT gene rs6354 polymorphism and family factors on the adaptability of Mongolian school-age children
10.3760/cma.j.cn371468-20211212-00724
- VernacularTitle:5-HTT基因rs6354多态性与家庭因素对蒙古族学龄儿童适应性的影响
- Author:
Yang XIAO
1
;
Man ZHAO
;
Yisheng YANG
;
Yuling LI
Author Information
1. 内蒙古师范大学生命科学与技术学院，呼和浩特 010022
- Keywords:
Temperament;
Adaptability;
Gene polymorphism, rs6354;
School-age children
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(6):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of rs6354 polymorphism of 5-HTT gene and family factors on the adaptability of Mongolian school-age children.Methods:The adaptability of 453 primary school students was assessed based on the middle childhood temperament questionnaire(MCTQ). The polymorphism of 5-HTT gene rs6354 was determined by improved multiple ligase detection reaction(iMLDR) technology. SPSS18.0 statistical software was used for data processing and analysis.Results:(1) The adaptability scores of children with GG/GT and TT genotype at rs6354 locus of 5-HTT gene were(2.88±0.73) and(3.03±0.76). (2) Univariate analysis showed that the adaptability scores of Mongolian school-age children were significantly different among different education levels of their parents (father F=2.580, P=0.037; mother F=3.245, P=0.012). (3) Multiple regression analysis showed that mother's educational level( B=-0.079, P=0.010) and rs6354 polymorphism( B=0.165, P=0.041) were inflencing factors of the adaptability score of Mongolian school-age children. (4) Logistic regression analysis showed that father's education level was a significant impact factor of the adaptive level of Mongolian school-age children( B=0.453, P<0.05, OR=1.573, 95% CI=1.023-2.417). Conclusion:rs6354 polymorphism is weakly correlated with children's adaptability, and the education level of parents, especially fathers, may be an important factor affecting the adaptability of Mongolian school-age children.
