Research advance of the mechanism and treatment of septic cardiomyopathy
10.3760/cma.j.cn121430-20210623-00938
- VernacularTitle:脓毒性心肌损伤机制及治疗的研究进展
- Author:
Tuerxun DILIREBA
1
;
Chunbo YANG
;
Yi WANG
;
Qiongli DING
;
Xiangyou YU
Author Information
1. 新疆医科大学第一附属医院重症医学科，新疆维吾尔自治区乌鲁木齐 830054
- Keywords:
Sepsis;
Septic cardiomyopathy;
Infection;
Clinical diagnosis;
Pathogenesis;
Diagnosis and treatment
- From:
Chinese Critical Care Medicine
2022;34(10):1112-1115
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by dysregulation of the body's response to infection. It is one of the common and serious complications in clinically critical patients with trauma, burn, shock, infection, etc., with high morbidity and mortality. Although the treatment of sepsis has made great achievements in clinical practice, the mortality of patients with sepsis is still increasing due to its secondary complications. Septic cardiomyopathy (SCM) is one of the major complications that threaten septic patient's life. SCM refers to myocardial dysfunction with the aggravation of the primary disease, which is manifested by biventricular dilatation accompanied by a decrease in left ventricular ejection fraction (LVEF). It is one of the major complications that threaten the life of patients with sepsis. The existing research shows that the mechanism of SCM includes myocardial mitochondrial dysfunction, myocardial cell apoptosis, calcium circulation disorder and its treatment including conventional treatment, β 1 receptor blocker treatment and traditional Chinese medicine treatment, etc. This paper reviewed the pathogenesis of SCM and its related, in order to provide references for the rational diagnosis and treatment of SCM.
