Research progress on the relationship between gut-liver axis disorder and sepsis
10.3760/cma.j.cn121430-20210913-01364
- VernacularTitle:肠-肝轴紊乱与脓毒症关系的研究进展
- Author:
Haobing SHI
1
;
Qianhao HOU
;
Lijun LIAO
Author Information
1. 同济大学附属东方医院麻醉与重症医学科，上海 200120
- Keywords:
Sepsis;
Gut-liver axis;
Gut microbiota;
Intestinal barrier
- From:
Chinese Critical Care Medicine
2022;34(7):769-772
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by an uncontrolled host response to infection. The mechanism of sepsis is extremely complicated and the mortality is still high. Persistent researches provide an important way to break through the "bottleneck" of clinical diagnosis and treatment of sepsis. In recent years, more and more studies have shown that gut-liver axis disorders, especially those caused by intestinal dysbiosis, intestinal barrier dysfunction, abnormal liver immune function, and bile acid metabolism disorders, play an important role in the occurrence and development of sepsis. This review describes the research progress of gut-liver axis disorders in the pathogenesis of sepsis for providing new ideas for clinical treatment.
