Expression of uric acid and cystatin C in serum of older adult patients with diastolic heart failure and their correlation with ventricular remodeling
10.3760/cma.j.cn341190-20210610-00666
- VernacularTitle:尿酸、胱抑素C在老年舒张性心力衰竭患者血清中的表达及其与心室重构的相关性
- Author:
Lijie WANG
1
;
Yuxiang LIU
;
Yu LI
;
Bingyu ZHANG
Author Information
1. 辽宁省金秋医院综合老年医学科三病房,沈阳 110016
- Keywords:
Heart failure,diastolic;
Ventricular remodeling;
Stroke volume;
Echocardiography,stress;
Retrospective studies;
Uric acid;
Cystatin C;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2022;29(11):1624-1628
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of serum uric acid and cystatin C in older adult patients with diastolic heart failure and their correlation with ventricular remodeling.Methods:The clinical data of 173 older adult patients with diastolic heart failure (patient group) and 144 older adult patients who had normal heart function (control group) who received treatment in Liaoning Jinqiu Hospital from January 2018 to January 2020 were retrospectively analyzed. Left ventricular end-diastolic diameter, left ventricular mass index, serum uric acid and cystatin C levels were compared between the two groups. These indices were also compared between patients with different classes of heart failure. Serum uric acid and cystatin C levels were correlated with left ventricular end-diastolic diameter and left ventricular mass index.Results:Left ventricular end-diastolic diameter, left ventricular mass index, and serum uric acid and cystatin C levels in the patient group were (46.82 ± 4.56) mm, (117.45 ± 24.51) g/m 2, (380.23 ± 115.85) μmol/L, (1.41 ± 0.51) mg/L, respectively, which were significantly higher than (45.8 ± 3.96) mm, (111.19 ± 19.30) g/m 2, (333.65 ± 89.02) μmol/L, (1.06 ± 0.34) mg/L, respectively in the control group ( t = 2.10, 2.48, 3.95, 7.02, all P < 0.05). Serum uric acid level in patients with class IV heart failure was (432.48 ± 157.64) μmol/L, which was significantly higher than (355.22 ± 106.56) μmol/L and (379.89 ± 93.43) μmol/L in patients with class II and class III heart failure ( F = 5.18, P < 0.05). Pearson correlation analysis showed that serum uric acid level was positively correlated with left ventricular end-diastolic diameter ( r = 0.17, P < 0.05) and left ventricular mass index ( r = 0.18, P < 0.05) in older adult patients with diastolic heart failure. Conclusion:Serum uric acid plays an important role in the occurrence and development of diastolic heart failure in older adults. Serum uric acid level can help measure the degree of ventricular remodeling to some extent.
