Current developments of bioanalytical sample preparation techniques in pharmaceuticals
- Author:
G.Ingle RAHUL
1
;
Zeng SU
;
Jiang HUIDI
;
Fang WEI-JIE
Author Information
1. Institute of Drug Metabolism and Pharmaceutical Analysis,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China;Hangzhou Institute of Innovative Medicine,Zhejiang University,Hangzhou,310016,China
- Keywords:
Bioanalysis;
Biological matrices;
Matrix effect;
Microextraction;
Sample preparation technique
- From:
Journal of Pharmaceutical Analysis
2022;12(4):517-529
- CountryChina
- Language:Chinese
-
Abstract:
Sample preparation is considered as the bottleneck step in bioanalysis because each biological matrix has its own unique challenges and complexity.Competent sample preparation to extract the desired analytes and remove redundant components is a crucial step in each bioanalytical approach.The matrix effect is a key hurdle in bioanalytical sample preparation,which has gained extensive consideration.Novel sample preparation techniques have advantages over classical techniques in terms of accuracy,automation,ease of sample preparation,storage,and shipment and have become increasingly popular over the past decade.Our objective is to provide a broad outline of current developments in various bioanalytical sample preparation techniques in chromatographic and spectroscopic examinations.In addition,how these techniques have gained considerable attention over the past decade in bioanalytical research is mentioned with preferred examples.Modern trends in bioanalytical sample preparation techniques,including sorbent-based microextraction techniques,are primarily emphasized.
