Advances in etiology and pathogenesis of orbital lymphoma
10.3760/cma.j.cn115989-20191023-00463
- VernacularTitle:眼眶淋巴瘤的病因及发病机制研究进展
- Author:
Mei SUN
1
;
Jianmin MA
Author Information
1. 首都医科大学附属北京同仁医院眼科 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室，北京 100730
- Keywords:
Orbit lymphoma;
Cytogenetics;
Immunity;
Antigen
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(11):1108-1113
- CountryChina
- Language:Chinese
-
Abstract:
Orbital lymphomas (OLs) are the common malignant tumor of the ocular adnexa.According to the source of abnormally proliferating lymphocytes, OLs can be further divided into several subtypes.The etiology and pathogenesis of OLs are still controversial.The current researches on OLs have shown that the etiology and pathogenesis of the disease are mainly related to genetic abnormalities of lymphocytes, abnormal immunosuppression, autoimmune diseases and chronic antigenic stimulation.However, there is no real lymphatic drainage system in the eye.Only a mucosa-associated lymphoid tissue (MALT) system extends from the lacrimal glands to the conjunctiva and lacrimal duct, so the pathogenesis of OLs is still unique.And the etiology of different OLs subtypes is quite different.For example, different chromosomal aberrations can cause varying subtypes of OLs, and various OLs subtypes have diverse predispositions in different autoimmune diseases.Researches on the etiology and pathogenesis of OLs at home and abroad were reviewed in this article to provide a reference for its clinical diagnosis and treatment.
