Role of NLRP3 inflammasome signaling pathway in the occurrence and development of diabetic keratopathy

VernacularTitle:NLRP3炎症小体信号通路在糖尿病角膜病变发生和发展中的作用
Author: Luqin WAN ¹ ; Qingjun ZHOU ; Lixin XIE
Author Information

1. 山东第一医科大学附属眼科研究所　山东第一医科大学附属青岛眼科医院，青岛　266071
Keywords: Diabetes/complications; Diabetic keratopathy; Inflammasomes/metabolism; Nucleotide-binding oligomerization domain-like receptor protein 3
From: Chinese Journal of Experimental Ophthalmology 2022;40(7):680-684
CountryChina
Language:Chinese
Abstract: Diabetic keratopathy is a chronic complication of diabetes caused by abnormal metabolites accumulation, oxidative stress, abnormal inflammation and corneal neuropathy.It can result in delayed corneal epithelial healing and decreased corneal sensitivity under the stimulation of ocular trauma or surgery which bring great challenges to clinicians.Activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammatory is one of the factors that cause chronic complications of diabetes, and is also an important factor for delaying the healing of diabetic wounds.The NLRP3 inflammatory signaling pathway is closely related to corneal oxidative stress, delayed epithelium healing and development of corneal neuropathy.In this paper, the research status and prospects of NLRP3 inflammatory signaling pathway and diabetic keratopathy were reviewed to provide new ideas for studying the mechanism and treatment of diabetic keratopathy.